Cancer

Rare Her2 mutations may not always spur breast cancers on their own

Results of a new laboratory study by Johns Hopkins Kimmel Cancer Center researchers suggests that some rare “missense” mutations in the HER2 gene are apparently not—on their own—capable of causing breast cancer growth or spread. In a related finding, the research team said such mutations, which are found in about five percent of breast cancers, may, thus, also fail to predict response to anti-cancer drugs that target the HER2 gene, unlike the more common alterations of the gene that amplify or overexpress it.

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